Selected Faculty Publications

• Jennifer Brielmaier

  Selected Publications

  Brielmaier J. The Woman Born Without a Cerebellum: A Real-Life Case Adapted for Use in an Undergraduate Developmental and Systems Neuroscience Course. Journal of Undergraduate Neuroscience Education. 2016;15(1):C1.

  Brielmaier J, Senerth JM, Silverman JL, Matteson PG, Millonig JH, DiCicco-Bloom E, Crawley JN. Chronic desipramine treatment rescues depression-related, social and cognitive deficits in Engrailed-2 knockout mice. Genes Brain Behav. 2014 Mar;13(3):286-298.

  Brielmaier J, Matteson PG, Silverman JL, Senerth JM, Kelly S, Genestine M, Millonig JH, DiCicco-Bloom E, Crawley JN. Autism-relevant social abnormalities and cognitive deficits in engrailed-2 knockout mice. PLoS One. 2012; 7(7):e40914.

  Brielmaier J, McDonald CG, Smith RF. Effects of acute stress on acquisition of nicotine conditioned place preference in adolescent rats: a role for corticotropin-releasing factor 1 receptors. Psychopharmacology (Berl). 2012 Jan; 219(1):73-82.

  Prager EM, Brielmaier J, Bergstrom HC, McGuire J, Johnson LR. Localization of mineralocorticoid receptors at mammalian synapses. PLoS One. 2010 Dec 15; 5(12):e14344.

  Brielmaier JM, McDonald CG, Smith RF. Nicotine place preference in a biased conditioned place preference design. Pharmacol Biochem Behav. 2008 Mar; 89(1):94-100.

  McDonald CG, Eppolito AK, Brielmaier JM, Smith LN, Bergstrom HC, Lawhead MR,Smith RF. Evidence for elevated nicotine-induced structural plasticity in nucleus accumbens of adolescent rats. Brain Res. 2007 Jun 2; 1151:211-218.

  Brielmaier JM, McDonald CG, Smith RF. Immediate and long-term behavioral effects of a single nicotine injection in adolescent and adult rats. Neurotoxicol Teratol. 2007 Jan-Feb;29(1):74-80.

  Smith LN, McDonald CG, Bergstrom HC, Brielmaier JM, Eppolito AK, Wheeler TL,

  Falco AM, Smith RF. Long-term changes in fear conditioning and anxiety-like behavior following nicotine exposure in adult versus adolescent rats. Pharmacol Biochem Behav. 2006; 85(1):91-97.

  View Full Biography

• Linda Doss Chrosniak

  Research Interests: learning and memory processes in both humans and animals

  Selected Publications

  Kashani, M., Eliasson, A., Chrosniak, L. D., Vernalis, M. (2010). Taking aim at nurse stress: A call to action. Military Medicine, 175, 96-100.

  Chrosniak, L. D., Smith, L. N., Flinn, J. M., McDonald, C. & Jones, B. F. (2006). Effects of enhanced zinc in drinking water on spatial memory and fear conditioning. Journal of Geochemical Exploration, 88, 91-94.

  Riskind, J. H., Williams, N. L., Gessner, T. G., Chrosniak, L. D., & Cortina, J (2000). A cognitive vulnerability to anxiety and danger: Looming maladaptive style. Journal of Personality and Social Psychology, 29, 837-852.

  View Full Biography

• Doris Bitler Davis

  Research Interests: Animal behavior and cognition, especially communication, social hierarchy, and the effects of domestication; the teaching of psychology

  Selected Publications

  Artz, B. and Davis, D. B. (2017).  Green Care: A review of the benefits and potential of animal-assisted care farming.  Animals, 7, 31. doi:10.3390/ani7040031

  Davis, D. B. (2017).  Exam question sequencing effects and context cues.  Teaching of Psychology, 44(3), 263-267.

  Davis, D. B. (December 12, 2016).  In praise of the humble quiz: A compendium of research findings. College Teaching, 7, 1-3. doi 10.1080/87567555.2016.1232695

  Davis, D. B. (2016). Familiarity versus understanding: A formative assessment.  College Teaching, 64(4), 228-229.

  McElroy, P., & Davis, D. B. (2016). Using quizzes to improve exam scores. Innovations in Teaching & Learning Conference Proceedings, 8.

  Davis, D. B. (2015). In their own best interest: Data-based decisions in the classroom.  Innovations in Teaching & Learning Conference Proceedings, 7(1), 90.

  View Full Biography

• Theodore Constantine Dumas

  Research Interests: Neural substrates of memory, neural and cognitive development, stress and behavioral control, real-time brain activity focus in a multidisciplinary setting

  Selected Publications

  McHail, D.G., Dumas, T.C. (2020) Hippocampal gamma rhythms during Y-maze navigation in the juvenile rat. Hippocampus. 30(5):505-525.

  Zhou, S., DeFranco, J.P., Blaha, N.T., Dwivedy, P., Culver, A., Nallamala, H., Chelluri, S., Dumas, T.C. (2019) Aversive conditioning in the tardigrade, Dactylobiotus dispar. Journal of Experimental Psychology: Animal Learning and Cognition. 45(4):405-412.

  Keith, R.E., Azcarate, J.M., Keith, M.J., Hung, C.W., Badakhsh, M.F., Dumas, T.C. (2018) Direct intracellular signaling by the carboxy terminus of NMDA receptor GluN2 subunits regulates dendritic morphology in hippocampal CA1 pyramidal neurons. Neuroscience. 396:138-153.

  Valibeigi N., McHail D.G., Carmen L. Kimball C.L., Dumas T.C. Barnes Maze Testing in Juvenile Rats. (2018) Bio-protocol. 8(22):1-12.

  Dumas, T.C., Uttaro, M.R., Barriga, C., Brinkley, T., Halavi, M., Wright, S.N., Ferrante M., Evans, R.C., Hawes, S.L., Sanders, E.M. (2018) Removal of area CA3 from hippocampal slices induces postsynaptic plasticity at Schaffer collateral synapses that normalizes CA1 pyramidal cell discharge. Neuroscience Letters. 678:55-61.

  Sanders, E.M., Nyarko-Odoom, A.O., Zhou, K.C., Nguyen, M.A., Liao, H.H., Keith, M., Pyon, J., Kozma, A., Sanyal, M., McHail, D.G., Dumas T.C. (2018) Separate functional properties of NMDARs regulate distinct aspects of spatial cognition. Learn. Mem. In press.

  McHail, D.G., Valibeigi, N., Dumas, T.C. (2018) Barnes maze for juvenile rats delineates the emergence of spatial navigation ability. Learn. Mem. 25(3):138-146.

  Stoneham ET, McHail DG, Boggs KN, Albani SH, Carty JA, Evans RC, Hamilton KA, Saadat VM, Hussain S, Greer ME, Dumas TC. (2017) Functional perturbation of forebrain principal neurons reveals differential effects in novel and well-learned tasks. Brain Res. 1671:1-13.

  Simon DM, Charkhkar H, St John C, Rajendran S, Kang T, Reit R, Arreaga-Salas D, McHail DG, Knaack GL, Sloan A, Grasse D, Dumas TC, Rennaker RL, Pancrazio JJ, Voit WE. (2017) Design and demonstration of an intracortical probe technology with tunable modulus. J. Biomed. Mater. Res. A. 105(1):159-168.

  Knaack, G.L., McHail, D.G., Borda, G., Beom, S.K., Peixoto, N., Cogan, S.F., Dumas, T.C., Pancrazio, J.J. (2016) In vivo Characterization of Amorphous Silicon Carbide as a Biomaterial for Chronic Neural Interfaces. Front. Neurosci. Neural Tech. 10:301.

  Gardner, R.S., Uttaro, M.R., Fleming, S.E., Suarez, D.F., Ascoli, G.A., Dumas, T.C. (2016) Differential Arc expression in the hippocampus and striatum during the transition from attentive to automatic navigation on a plus maze. Neurobiol. Learn. Mem. 131:36-45.

  Charkhkar, H., Knaack, G.L., McHail, D.G., Mandal, H.S., Peixoto, N., Rubinson, J.F., Dumas, T.C., Pancrazio, J.J. (2016) Chronic intracortical neural recordings using microelectrode arrays coated with PEDOT-TFB. Acta Biomaterialia. 32:57-67.

  Hawes, S.L., Evans, R.C., Unruh, B.A., Benkert, E.E., Gillani, F., Dumas, T.C., Blackwell, K.T. (2015) Multimodal Plasticity in Dorsal Striatum While Learning a Lateralized Navigation Task. J. Neurosci. 35(29):10535-49.

  Albani, S.H., Andrawis, M.M, Abella, R.J., Fulghum, J., Vafamand, N., Dumas, T.C. (2015) Behavior in the elevated plus maze is differentially affected by testing conditions in rats under and over three weeks of age. Frontiers in Behavioral Neuroscience. 9:31.

  Mandal, H.S., Kastee, J., McHail, D.G., Rubinson, J.F., Pancrazio, J.J., Dumas, T.C. (2015) Improved Poly(3,4-ethylenedioxythiophene) (PEDOT) for neural stimulation. Neuromodulation. 18(8):657-63.

  McHail, D.G. and Dumas, T.C. (2015) Multiple forms of metaplasticity at a single hippocampal synapse during late postnatal development. Dev. Cog. Neurosci. 12:145-154.

  Mandal, H.S., Kastee, J., McHail, D.G., Rubinson, J.F., Pancrazio, J.J., Dumas, T.C. (2015) Improved Poly(3,4-ethylenedioxythiophene) (PEDOT) for neural stimulation. Neuromodulation. 18:657-663.

  *Albani, S.H., *McHail, D.G., Dumas, T.C. (2014) Developmental studies of the hippocampus and hippocampal-dependent behaviors: Insights from interdisciplinary studies and tips for new investigators. (*authors contributed equally) Neurosci. Biobehav. Rev. 43C:183-190.

  Mandal, H.S., Knaack, G.L., Charkhkar, H., McHail, D.G., Kastee, J., Dumas, T.C., Peixoto, N., Rubinson, J.F., Pancrazio, J.J. (2014) Improving the performance of poly(3,4-ethylenedioxythiophene) (PEDOT) for brain machine interface applications. Acta Biomaterialia, 10:2446-2454.

  Gardner, R.S., Uttaro, M.R., Fleming, S.E., Suarez, D.F., Ascoli, G.A., Dumas, T.C.  (2013) A secondary working memory challenge preserves primary place strategies despite over-training. Learn. Mem. 20(11):648-56

  *Blair, M.G., *Nguyen, N.N-Q., Albani, S.H., L'Etoile, M.M., Andrawis M.M., Owen, L.M., Oliveira, R.F., Johnson, M.W., Purvis, D.L., Sanders, E.M., Stoneham, E.T., Dumas, T.C. (2013) Developmental changes in structural and functional properties of hippocampal AMPA receptors parallels the emergence of deliberative spatial navigation in juvenile rats (*authors contributed equally). J. Neurosci. 33:12218-28.

  Sanders, E.M., Nguyen, M.A., Zhou, K.C., Hanks, M.E., Yusuf, K.A., Cox, D.N., & Dumas T.C. (2013) Developmental modification of synaptic NMDAR composition and maturation of glutamatergic synapses: Matching postsynaptic slots with receptor pegs. Biol. Bull. 224:1-13.

  Dumas, T.C. (2012) Postnatal alterations in induction threshold and expression magnitude of long-term potentiation and long-term depression at hippocampal synapses. Hippocampus. 22:188-99.

  Dumas, T.C., Gillette, T., Ferguson, D., Hamilton, K. & Sapolsky, R.M. (2010) Anti-glucocorticoid gene therapy reverses the impairing effects of elevated corticosterone on spatial memory, hippocampal neuronal excitability, and synaptic plasticity. J. Neurosci. 30:1712-1720.

  Stoneham, E.M., Sanders, E.M., Sanyal, M., & Dumas, T.C. (2010) Late postnatal maturation of long-lasting activity-dependent synaptic plasticity in the hippocampus. Biol. Bull. 219:81-99.

  View Full Biography

• Jane M Flinn

  Research Interests: The role of metals in learning and memory, including their role in Alzheimer's disease and traumatic brain injury (TBI)

  Selected Publications

  Stephen L P Lippi, S.L., Kakalec, P.A., Smith, M.L., Flinn, J.M.. ( 2020) Wheel-running behavior is negatively impacted by zinc administration in a novel dual transgenic mouse model of AD. Frontiers in Neuroscience, section Sleep and Circadian Rhythms.

  Neely, C.L.C., Boggs, K.N., Pedemonte, K.A. Flinn, J.M. (2019). Nest Building Behavior as an Early Indicator of Behavioral Deficits in Mice. J. Vis. Exp. (152), e60139, doi:10.3791/60139

  Neely, C.L.C., Lippi, S.L.P., Lanzirotti, A., Flinn J.M. (2019). Localization of Free and Bound Metal Species through X-Ray Synchrotron Fluorescence Microscopy in the Rodent Brain and Their Relation to Behavior. Brain Sciences. 2019 March 28, 9(4).

  Lippi, S.L,P., Craven, K.M., Hernandez, C, Grant G. Flinn J.M. (2019).Perfusion Alters Free Zinc Levels in the Rodent Brain. J Neurosci Methods.315:14-16.

  Lippi, S.L,P.,  Smith, M.M., Flinn J.M.(2018).   A novel hAPP/htau mouse model of Alzheimer’s disease: Inclusion of APP with tau exacerbates behavioral deficits and zinc administration heightens tangle pathology. Frontiers in Aging Neuroscience, in press.

  Craven, K.M.,  W.R., Hernandez C.M.,  Flinn, J.M. (2018). Zinc Exacerbates Tau Pathology in a Tau Mouse Model. J. Alz.Dis.4(2):617-630.

   Neely, C., Lane, C., Torres, J., Flinn, J.  (2018). The effect of gentle handling on depressive-like behavior in adult male mice: Considerations for human and rodent interactions in the laboratory. Behav. Neurol.  Mar 6;2018:2976014.

  Tripona, R.G. , Judit Oláh, J., Nasira, T. ,  Csincsika,L. ,  Lok Li, C. ,  Szunyogh, S., Gonge, H., Flinn,  J.M., Ovádic, J., Imre Lengyel, I.  (2018) Localization of the Zinc Binding Tubulin Polymerization Promoting Protein in the Mice and Human Eye. J.  Trace Elem. Med. and Bio. Available on line Dec 2017.

  Boggs K.N.,   Kakalec, P.A., Smith, M.L., Howell, S.N.,  Flinn, J.M. (2017). Circadian wheel running behavior is altered in an APP/E4 mouse model of late onset Alzheimer's disease. Physiol. and Behav. 182, 137-142.

  Flinn J.M (2016). Amazing Papers in Neuroscience Both Genetic and Environmental Changes Can Enhance Learning and Memory. J.U.N.E. 15(1): R14-16.

  Thompson, R.B., Reffatto,V., Bundy, J.G., Flinn, J.M., Lanzirotti, A., Jones, A.E., McPhailg, D.S., Fearn, S., Boldtd, K.,Ueffingd, M., Ratub, S.S., Pauleikhoff, L., Bird, A.C., Lengyel, I. (2015) Identification of hydroxyapatite spherules provides new insight into sub-retinal pigment epithelial deposit formation in the aging eye.  Proc. Natl. Acad. Sci. U S A. 112(5):1565 – 70. 

  Maguire L., Wanschura P.B., Battaglia M.M., Howell, S.N., Flinn, J.M.  (2014). Participation In Active Singing Over A 4-Month Period Leads To Cognitive Improvements In A Group of Patients with Dementia. J. Am. Geriatr. Soc. 63(4):815-6. 

  Flinn, J.M., Bozzelli, P.L., Adlard, P.A., Railey, A.M. (2014). Spatial memory deficits in a mouse model of late-onset Alzheimer’s disease are caused by zinc supplementation and correlate with amyloid-beta levels. Frontiers in Aging.  2014, Oct 22; 6:74.  

  Graybeal, J.J.,  Bozzelli^, P.L.,  Graybeal, L.G., McKnight^, P.E.,  Cox^, D.N.,  (2014) Flinn^, J.M. Human ApoE ε4 alters circadian rhythm activity, IL-1β and GFAP in CRND8 mice.  J. Alzheimers Dis. 2015; 43(3):823-34.  

  Davidson, D., Chrosniak, L D., Wanschura, P. B Flinn, J.M.  (2014) Indications  of   Reduced Prefrontal Cortical Function in Chronically Homeless Adults. J. Comm. Ment. Hlth. 50:548-552. 

  Flinn, J.M.,  Kakalec, P., Tappero, R., Jones,  B.J., Lengyel, L. (2014)  Correlations  in distribution and concentration of calcium, copper and iron with zinc in isolated extracellular deposits associated with age-related macular degeneration. Metallomics.  6 (7):  1223-1228.

  Railey, A.M., Groeber, C.M., Flinn, J.M. (2011) The Effect of Metals on Spatial Memory in a Transgenic Mouse Model of Alzheimer's Disease. J. Alzheimer’s Dis. 24(2) 375-381

  Railey, A.M., Micheli, T.L.,Wanschura, P.B., Flinn, J.M. (2010). Alterations in fear response and spatial memory in pre- and post- natal zinc supplemented rats: remediation by copper. Physiology and Behavior. 100(2):95-100.

  Linkous, D. H.. Adlard P.A., Wanschura P.B., Conko K.M. and Flinn J.M. (2009).The effects of enhanced zinc on spatial memory and plaque formation in transgenic mice. J, Alzheimer’s Disease. 18(3) 541-551.

  Linkous, D.H., Flinn, J.M., Koh, J.Y., Lanzirotti, A., Bertsch, P., Jones, B.F., Fredrickson, C.J. (2008). Evidence that the ZNT-3 protein controls the total amount of elemental zinc in synaptic vesicles. J. Histochem. and Cytochem. 56(1):3-6.

  Graybeal, J.J.,  Bozzelli^, P.L.,  Graybeal, L.G.,  McKnight^, P.E.,  Cox^, D.N.,  Flinn^, J.M. Human ApoE ε4 alters circadian rhythm activity, IL-1β and GFAP in CRND8 mice.   In press,  J . Alz Dis. 

  Flinn, J.M.,  Bozzelli, P.L.,  Adlard,  P.A.,  Railey, A.M. Spatial memory deficits in a mouse model of late-onset Alzheimer’s disease are caused by zinc supplementation and correlate with amyloid-beta levels. In press,  Frontiers in Aging.

  Participation In Active Singing Over A 4-Month Period Leads To Cognitive Improvements In A Group Of Patients With Dementia.  Maguire L., Wanschura P.B., Battaglia M.M., Howell .SN., Flinn J.M.  Accepted in J.Am. Gerontol Soc.

  Davidson, D., Chrosniak, L D., Wanschura, P. B Flinn, J.M.  (2014) Indications of Reduced Prefrontal Cortical Function in Chronically Homeless Adults.  Journal of Community and Mental Health. 50:548-552

  Flinn, J.M.,  Kakalec, P., Tappero, R., Jones,  B.J., Lengyel, L. (2014) Correlations in distribution and concentration of calcium, copper and iron with zinc in isolated extracellular deposits associated with age-related macular degeneration.  Cover article,  Metallomics.  6 (7):  1223-1228.

  View Full Biography

• Allison E Jack

  Research Interests: Autism spectrum disorders, fMRI, cerebellum, sex differences, social perception

  Selected Publications

  Jack, A. & Pelphrey, K.A. (2017). Understudied populations within the autism spectrum: Current trends and future directions in neuroimaging research. J Child Psychol Psychiatr, 58: 411-35. doi:10.1111/jcpp.12687

  Jack, A., Keifer, C.M., & Pelphrey, K.A. (2017). Cerebellar contributions to biological motion perception in autism and typical development. Hum Brain Mapp, 38:1914-32. doi:10.1002/hbm.23493 PMCID: PMC5342927 

  Gordon, I.*, Jack, A.* (*Co-first authors), Pretzsch, C. M., Vander Wyk, B., Leckman, J.F., Feldman, R., & Pelphrey, K. (2016). Intranasal oxytocin enhances connectivity in the neural circuitry supporting social motivation and social perception in children with autism. Sci Rep, 6: 35054. doi:10.1038/srep35054

  Jack, A. & Pelphrey, K. A. (2015). Neural correlates of animacy attribution include neocerebellum in healthy adults. Cereb Cortex, 25:4240-47. doi:10.1093/cercor/bhu146 PMCID: PMC4626832

  Jack, A. & Morris, J. P. (2014). Neocerebellar contributions to social perception in adolescents with autism spectrum disorder. Dev Cogn Neurosci, 10:77-92. doi:10.1016/j.dcn.2014.08.001

  Jack, A., Connelly, J.J., & Morris, J.P. (2012). DNA methylation of the oxytocin receptor gene predicts neural response to ambiguous social stimuli. Front Hum Neurosci, 6:280. doi:10.3389/fnhum.2012.00280

  Jack, A., Englander, Z.A., & Morris, J.P. (2011). Subcortical contributions to effective connectivity in brain networks supporting imitation. Neuropsychologia, 49, 3689-98. doi:10.1016/j.neuropsychologia.2011.09.024

  View Full Biography

• Craig McDonald

  Research Interests: Cognitive control, action monitoring, selective attention

  Selected Publications

  Beatty PJ, Buzzell GA, Roberts DM & McDonald CG (2020) Contrasting time and frequency domains: ERN and induced theta oscillations differentially predict post-error behavior. Cognitive, Affective & Behavioral Neuroscience 12: 636-647.

  Beatty PJ, Buzzell GA, Roberts DM & McDonald CG (2018) Speeded response errors and the error-related negativity modulate early sensory processing. NeuroImage 183: 112-120.

  Buzzell GA, Beatty PJ, Paquette NA, Roberts DM & McDonald CG (2017) Error-induced blindness: error detection leads to impaired sensory processing and reduced accuracy at short response-stimulus intervals. Journal of Neuroscience 37(11): 2895-2903.

  Roberts DM, Fedota JR, Buzzell GA, Parasuraman R & McDonald CG (2014) Prestimulus oscillations in the alpha band of the EEG are modulated by the difficulty of feature discrimination and predict activation of a sensory discrimination process. Journal of Cognitive Neuroscience 26(8): 1615-1628.
  

   

   

  View Full Biography

• James C Thompson

  Research Interests: Examining how we recognize human movement and make sense of other peoples' actions and how this can be applied in specialized settings such as surveillance and in conditions in which human movement recognition may be impaired.

  Selected Publications

  Wheaton KJ, Thompson JC, Syngeniotis A, Abbott DF, Puce A. (2004) Viewing the motion of human body parts activates different regions of premotor, temporal, and parietal cortex. Neuroimage 22:277-88.

  Thompson JC, Clarke M, Stewart T, Puce A. (2005) Configural processing of biological motion in human superior temporal sulcus. J Neurosci. 25:9059-66.

  View Full Biography

• Martin Wiener

  Research Interests: Cognitive Neuroscience, Time Perception, Space Perception, Datasharing

  Selected Publications

  Wiener, M., Michaelis, K., & Thompson J. (2016) Distance Reproduction is Influenced by Prior Stimulus History via the hippocampus and retrosplenial cortex. Human Brain Mapping, 37(9), 3172–3187.

  Wiener, M., & Thompson, J. (2015). Repetition Enhancement and Memory Effects for Duration. NeuroImage, 113, 268-278.

  Wiener, M., Kliot, D., Turkeltaub, P.E., Hamilton, R.H., Wolk, D., & Coslett, H.B. (2012). Parietal influence on temporal encoding indexed by simultaneous transcranial magnetic stimulation and electroencephalography. Journal of Neuroscience, 32(35), 12258-12267

  Wiener, M., Lohoff, F.W., & Coslett, H.B. (2011). Double dissociation of dopamine genes and timing in humans. Journal of Cognitive Neuroscience, 23(10), 2811-2821.

  Wiener, M., Turkeltaub, P., & Coslett, H.B. (2010). The image of time: a voxel-wise meta-analysis. NeuroImage, 49(2), 1728-1740.

  View Full Biography